Published: 13 March 2026
Author(s): Andrea Galeazzo Rigutini, Maurizio Paciaroni, Maria Giulia Mosconi, Virginia Cancelloni, Chiara Urbini, Michele Marvardi, Carmen Rapuano, Allegra Gaboni, Alessandro Bufi, Tommaso Bucci, Cecilia Becattini, Gregory Y.H. Lip, Valeria Caso
Issue: March 2026
Section: Original Article

Stroke is a major global cause of morbidity and mortality and is frequently complicated by early cardiovascular events, collectively referred to as stroke-heart syndrome (SHS)[1,2]. The SHS encompasses a spectrum of early cardiovascular complications that occur within 30 days of an acute ischaemic stroke, involving either the emergence of new cardiac conditions or the destabilization of pre-existing ones. These include acute myocardial infarction (AMI), heart failure (HF), systolic dysfunction - including Takotsubo cardiomyopathy - arrhythmias (such as atrial fibrillation [AF] and other electrocardiographic abnormalities), and sudden cardiac death[2–5].

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