Gastrointestinal bleeding (GIB) is a major cause of hospital admission, and in most cases has a iathrogenic cause. Administrative data from the United States report more than 400,000 hospital admissions per year due to GIB [1], whereas international dedicated registries report an extremely variable incidence rate from 15 to 172/100,000 person-years for upper GIB, and from 20.5 to 87/100,000 person-years for lower GIB [2].