Hepatic encephalopathy (HE) is a potentially reversible disorder characterized by neuropsychiatric abnormalities and motor disturbances ranging from mild alterations of cognitive and motor functions to coma and death [1,2]. This condition has been attributed to the combination of gut-derived toxins production, portosystemic shunts and liver dysfunction, leading to endotoxemia associated with systemic and cerebral inflammation [3]. The subclinical expression of HE is defined as minimal hepatic encephalopathy (mHE) [4].