Kidney involvement in Systemic Sclerosis (SSc) is primarily due to vasospasm induced by renal Raynaud's phenomenon, leading to hypoxia, impaired angiogenesis and microvascular dysfunction. Renal scleroderma vasculopathy (RSV) is the manifestation of this process, characterized by intrarenal stiffness with parenchymal thickness reduction, despite the glomerular filtration rate (GFR) remaining within the normal range [1]. Several markers, such as serum Creatinine (Cr) and Cystatin C (CysC) are avalaible to estimate GFR (eGFR) [2].
