February 2019
18 ArticlesNo Section
Profiling the hospital-dependent patient in a large academic hospital: Observational study
In older patients with acute illness, a condition of “hospital-dependence” may arise: patients get adapted to the hospital care and, once discharged, may experience health status decline, requiring... more
Syncope in the German Nationwide inpatient sample – Syncope in atrial fibrillation/flutter is related to pulmonary embolism and is accompanied by higher in-hospital mortality
Syncope is a common phenomenon in the general population. Although most of the causes are of benign origin, some comorbidities are accompanied by high mortality.We aimed to compare the in-hospital... more
The effect of compression stocking on leg edema and discomfort during a 3-hour flight: A randomized controlled trial
Compression stockings reduce the risk of thromboembolic complications, leg edema, and edema-related pain and discomfort during long-haul flights. The aim of this study was to assess if compression... more
Association of renin-angiotensin system inhibitors with long-term outcomes in patients with systolic heart failure and moderate-to-severe kidney function impairment
Although guidelines recommend that patients with heart failure with reduced ejection fraction (HFrEF) should be treated with renin-angiotensin system (RAS) inhibitors, the long-term efficacy of RAS... more
Letter to the Editor
Comment to “Impact of Daylight Saving Time on circadian timing system: An expert statement”. Authors' reply
We appreciated the sophisticated and learned dissertation by Dr. Martìn-Olalla [1], based on solid and interesting perspectives.
Comment to “Impact of Daylight Saving Time on circadian timing system: An expert statement”
The impact of Daylight Saving Time (DST) on daily life has gained a lot of attention in the past few years and, notably, in the past months since the European Commission addressed the issue. It was... more
Raynaud's phenomenon and inflammatory bowel disease: The possible role of microcirculation
Vascular pathology is increasingly more recognized as an extra-intestinal manifestation of Inflammatory Bowel Disease (IBD) [1,2]. Raynaud's phenomenon (RP), a syndrome characterized by recurrent... more
Haemoptysis as a presenting feature of hepatopulmonary disease
The report of haemoptysis as a presenting feature of hepatic-pulmonary disease [1] is testimony to the importance of hepatic-pulmonary disease in the differential diagnosis of haemoptysis. This... more
Frailty is associated with multimorbidities due to decreased physical reserve independent of age
We read the study of Vancampfort et al. entitled “Handgrip strength, chronic physical conditions and physical multimorbidity in middle-aged and older adults in six low- and middle income countries”... more
Physiological reaction following contrast medium administration: What kind of reaction is this?
Although adverse reactions following contrast medium (CM) application occur regularly in routine, radiologists are in most cases not familiar with the clinical reaction patterns. Therefore, the... more
Original Article
Association of systemic beta-defensin-1 and -20G/A DEFB1 gene polymorphism with Behçet's disease
Behçet's disease (BD) is a multisystem inflammatory disease of unknown etiology. Beta-defensins are antimicrobial peptides involved in epithelial host defense. To explore whether beta-defensins might... more
Factors associated with length of stay in hospital for men and women aged 85 and over: A quantile regression approach
Explore characteristics of hospital use for adults aged 85 and over in their last year of life and examine factors associated with cumulative overnight length of stay (LOS).
Iron supplementation for restless legs syndrome – A systematic review and meta-analysis
Iron supplementation, is recommended for the treatment of restless legs syndrome (RLS). We gathered evidence for the efficacy and safety of iron supplementation for RLS.
Reactive thrombocytosis in acute infectious diseases: Prevalence, characteristics and timing
Reactive thrombocytosis is known to occur in infectious, inflammatory and neoplastic diseases. However, the characteristics of its association with acute infections (ID) has not been systematically... more
Review Article
European and US guidelines for arterial hypertension: similarities and differences
Hypertension is one of the most common chronic diseases in adults and a leading cause of disability and mortality worldwide. Recently, new Guidelines for the diagnosis and management of hypertension... more
Special Article
Grantsmanship writing tips: the experimental design
Our prior editorials have discussed the basic principles of grantsmanship [1] and the writing approach for the background, hypothesis, specific aims sections [2]. Herein we present the effective... more
Grantsmanship writing tips: significance, innovation and impact
In this fourth and last special article on grantsmanship [1–3], we discuss the strategies to write competitive “Significance,” “Innovation,” and “Impact” sections, when required. Several sponsors... more
Grantsmanship writing tips: background, hypothesis and aims
In the current article, we discuss the effective writing strategies for research grant proposal's background/introduction and specific aims/objective sections. These key components are often found in... more