Published: 7 May 2016
Author(s): Silvio Garattini, Janus C. Jakobsen, Jørn Wetterslev, Vittorio Bertele’, Rita Banzi, Ana Rath, Edmund A.M. Neugebauer, Martine Laville, Yvonne Masson, Virginie Hivert, Michaela Eikermann, Burc Aydin, Sandra Ngwabyt, Cecilia Martinho, Chiara Gerardi, Cezary A. Szmigielski, Jacques Demotes-Mainard, Christian Gluud
Issue: May 2016
Section: Review Article

Using the best quality of clinical research evidence is essential for choosing the right treatment for patients. How to identify the best research evidence is, however, difficult. In this narrative review we summarise these threats and describe how to minimise them. Pertinent literature was considered through literature searches combined with personal files. Treatments should generally not be chosen based only on evidence from observational studies or single randomised clinical trials. Systematic reviews with meta-analysis of all identifiable randomised clinical trials with Grading of Recommendations Assessment, Development and Evaluation (GRADE) assessment represent the highest level of evidence.

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