In this issue of European Journal of Internal Medicine, Wang et al. present their meta-analysis on extended thromboprophylaxis of venous thromboembolism (VTE) in medical patients [1]. To comment on it, it is necessary to make some considerations. Definite evidence was obtained in the late 1990s and early 2000s that in hospital pharmacological prophylaxis of VTE was beneficial for nonsurgical patients and this nearly a quarter of a century after the benefit of VTE prophylaxis was demonstrated in the surgical setting.
