Published: 15 August 2025
Author(s): Raffaele Antonelli Incalzi, Claudio Pedone
Section: Commentary

Aging leads to progressive organ dysfunction, and many chronic degenerative diseases are characterized by accelerated aging of organs and apparatus. Thus, disentangling the effects of aging and age-related diseases is extremely difficult. For instance, according to the Global Burden of Disease Study (https://vizhub.healthdata.org/gbd-results/), the prevalence of ischemic heart disease is 15 % in the 65-69 years age group, 19 % in the 70-74 years age group, and 26 % in those with 75+ years of age; the corresponding figures for chronic obstructive pulmonary disease (COPD) are 10 %, 14 %, and 24 %.

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